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Phytogenic Feed Additive Enhance Innate and Humoral Immune Response to Newcastle Disease Virus Vaccination in Broiler Chickens
Abstract
Objective: The objective of this study was to evaluate the effects of a phytogenic feed additive (Biostrong 510), which contains Saponins to modulate the immune system of poultry and to improve vaccination efficacy. Materials and Methods: In this study, four groups of broiler chickens (40 each) were reared for 10 days under same conditions. Groups 1 and 2 were fed diets containing phytogenic feed additives (PFA) at 150 mg kg–1 (Biostrong 510, Delacon Biotechnik GmbH, Austria) whereas groups 3 and 4 continued to be fed without any PFA as control groups. Chickens in groups 1 and 3 were vaccinated with Newcastle disease vaccine (NDV-Lasota strain) at 14 days of age whereas groups 2 and 4 were left unvaccinated as controls. Immune organ/body weight ratio; phagocytic activity; nitric oxide, lysozyme and total antioxidant activity were measured. In addition, mean titers of heamagglutinating antibodies to NDV were determined. Results: This study showed that in comparison to the control groups, chickens fed Biostrong 510 demonstrated a significant increase in bursa/body weight ratio, significant increase in total antioxidant activity and phagocytic indexes. However, no significant effects were determined in nitric oxide and lysozyme concentration. Conclusion: Biostrong 510 has the potential to stimulate the innate immune response and enhance antibody production against NDV.
Keywords:
Broiler chicken, immunity, NDV, phytogenic feed additive, vaccinationArticle Metrics
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This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.
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Aly, S. M., Hafez, A. S., Nada, A. F. A., & Hussein , H. A. (2019). Phytogenic Feed Additive Enhance Innate and Humoral Immune Response to Newcastle Disease Virus Vaccination in Broiler Chickens. International Journal of Poultry Science, 18(2), 93–100. https://doi.org/10.3923/ijps.2019.93.100
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