Research Article Open Access

Efficacy of HVT-IBDV Vector Vaccine Against Recent Egyptian vvIBDV in Commercial Broiler Chickens

Authors

Hesham Sultan
Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Minoufiya University, Minoufiya , Egypt
|
Hussein A. Hussein
Department of Virology, Faculty of Veterinary Medicine, Cairo University, Giza, Egypt
|
Alaa G. Abd El-Razik
Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Minoufiya University, Minoufiya , Egypt
|
Sallah El-Balall
Department of Pathology, Faculty of Veterinary Medicine, Minoufiya University, Minoufiya, Egypt
|
Shaima M. Talaat
Department of Poultry and Rabbit Diseases, Faculty of Veterinary Medicine, Minoufiya University, Minoufiya , Egypt
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CORRESPONDING AUTHOR
Awad A. Shehata
Institute of Microbiology, Faculty of Veterinary Medicine, Leipzig University, Leipzig, Germany
Published on: October 15, 2012
DOI 10.3923/ijps.2012.710.717
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Abstract

The efficacy of a turkey herpesvirus (HVT-IBD) vector vaccine encoding the VP2 gene of Infectious Bursal Disease (IBD) was evaluated in comparison with classic vaccines on two commercial broiler chicken farms (A and B), with high levels of Maternal Derived Antibodies (MDA). The HVT-IBD vaccine was administrated into chickens of farm A at 1-day-old while intermediate and intermediate-plus vaccines were given at 1-and 14-day-old into chickens of farm B, respectively. An early significant seroconversion was detected at 21-day-old in chickens of farm A, while no significant serological response was detected in farm B at this time. The antibody level was significantly higher in chickens in farm A at 28-and 35-day-old. Moreover, HVT-IBD vaccine provided complete protection against recent Egyptian vvIBDV isolate. In conclusion, HVT-IBD vaccine has the ability to induce an immune response in birds with high levels of MDA and could protect against recent Egyptian vvIBDV isolates.

Keywords:

Infectious bursal disease, herpesvirus of Turkeys, recombinant viral vectored vaccines, very virulent IBDV

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Sultan, H., Hussein, H. A., El-Razik, A. G. A., El-Balall, S., Talaat, S. M., & Shehata , A. A. (2012). Efficacy of HVT-IBDV Vector Vaccine Against Recent Egyptian vvIBDV in Commercial Broiler Chickens. International Journal of Poultry Science, 11(11), 710–717. https://doi.org/10.3923/ijps.2012.710.717
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