Research Article Open Access

Exhibit Differential Functions of Various Antibiotic Growth Promoters in Broiler Growth, Immune Response and Gastrointestinal Physiology

Authors

D.N. Lee
Department of Animal Science, National Ilan University, Ilan 260, Taiwan
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S.R. Lyu
Department of Animal Science, National Ilan University, Ilan 260, Taiwan
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R.C. Wang
Department of Animal Science, National Ilan University, Ilan 260, Taiwan
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C.F. Weng
Institute of Biotechnology, National Dong Hwa University, Hualien 974, Taiwan
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CORRESPONDING AUTHOR
B.J. Chen
Department of Animal Science and Technology, National Taiwan University, Taipei 106, Taiwan
Published on: February 15, 2011
DOI 10.3923/ijps.2011.216.220
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Abstract

Six-hundred forty broilers were allotted into four dietary supplementation of none, 55 ppm bacitracin, 2.5 ppm nosiheptide, or 55 ppm Oxytetracycline (OTC) in a corn-soybean meal basal diet with eight pens in each treatment to investigate the effects of added various Antibiotic Growth Promoters (AGP) in diet on growth performance, immune response and gastrointestinal physiology. Data showed that nosiheptide supplementation but not bacitracin or OTC increased feed efficiency in starter period. The nosiheptide decreased the small intestine weight, IgA-positive cells along the intestinal tract and ileal mucosal secretory IgA (sIgA) concentration but bacitracin and OTC increased the IgA-positive cells in ileum. The nosiheptide supplementation group also elevated ileal sucrase and maltase activities and reduced the Lactobacillus counts in rectal contents as compared to the other treatment groups. In conclusion, the enhanced disaccharidase activity, diminished rectal Lactobacillus counts and reduced immune activated status are possibly the important factors for the improvement of feed efficiency of broilers on dietary nosiheptide supplementation from days 0-21.

Keywords:

Antibiotic growth promoters, immune response, broiler, microflora, small intestine

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How to Cite

Lee, D., Lyu, S., Wang, R., Weng, C., & Chen , B. (2011). Exhibit Differential Functions of Various Antibiotic Growth Promoters in Broiler Growth, Immune Response and Gastrointestinal Physiology. International Journal of Poultry Science, 10(3), 216–220. https://doi.org/10.3923/ijps.2011.216.220
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References

1.
Alexander, D.J., H.T. Morris, W.J. Pollitt, C.E. Sharpe and R.L. Eckford et al., 1998. Newcastle disease outbreaks in domestic fowl and turkeys in Great Britain during 1997. Vet. Rec., 143: 209-212.
2.
Arias, V.J. and E.A. Koutsos, 2006. Effects of copper source and level on intestinal physiology and growth of broiler chickens. Poult. Sci., 85: 999-1007.
3.
Dahlqvist, A., 1964. Method for assay of intestinal disaccharidases. Anal. Biochem., 7: 18-25.
4.
Dibner, J.J., C. Knight, G.F. Yi and J.D. Richards, 2007. Gut development and health in the absence of antibiotic growth promoters. Asian-Aust. J. Anim. Sci., 20: 1007-1014.
5.
Dibner, J.J. and J.D. Richards, 2005. Antibiotic growth promoters in agriculture: History and mode of action. Poult. Sci., 84: 634-643.
6.
Duncan, D.B., 1955. Multiple range and multiple F tests. Biometrics, 11: 1-42.
7.
Ferket, P.R., 2004. Alternatives to Antibiotics in Poultry Production: Responses, Practical Experience and Recommendations. In: Nutritional Biotechnology in the Feed and Food Industries, Lyons, T.P. and K.A. Jacques (Eds.). Nottingham University Press, Nottingham, UK., pp: 57-67.
8.
Guban, J., D.R. Korver, G.E. Allison and G.W. Tannock, 2006. Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius and reduced bile salt deconjugation in the ileum of broiler chickens. Poult. Sci., 85: 2186-2194.
9.
Jorgensen, H., X.Q. Zhao, K.E.B. Knudsen and B.O. Eggum, 1996. The influence of dietary fibre source and level on the development of the gastrointestinal tract, digestibility and energy metabolism in broiler chickens. Br. J. Nutr., 75: 379-395.
10.
Kim, Y.Y., D.Y. Kil, H.K. Oh and I.K. Han, 2005. Acidifier as an alternative material to antibiotics in animal feed. Asian-Aust. J. Anim. Sci., 18: 1048-1060.
11.
Klasing, K.C., 1998. Nutritional modulation of resistance to infectious diseases. Poult. Sci., 77: 1119-1125.
12.
Lee, D.N., C.F. Weng, Y.H. Cheng, T.Y. Kuo, J.F. Wu and H.T. Yen, 2003. Dietary glutamine supplementation enhances weaned pigs mitogen-induced lymphocyte proliferation. Asian-Aust. J. Anim. Sci., 16: 1182-1187.
13.
McGinnis, C.H. Jr., C.A. Johnson and J.E. Fox, 1978. The effect of nosiheptie, a new antibiotic, on body weight gain and feed efficiency in broiler chickens. Poult. Sci., 57: 1641-1645.
14.
Miles, R.D., G.D. Butcher, P.R. Henry and R.C. Littell, 2006. Effect of antibiotic growth promoters on broiler performance, intestinal growth parameters and quantitative morphology. Poult. Sci., 85: 476-485.
15.
Miller, T.L. and M.J. Wolin, 1974. A serum bottle modification of the Hungate technique for cultivating obligate anaerobes. Appl. Microbiol., 27: 985-987.
16.
NRC., 1994. Nutrient Requirements of Poultry. 9th Edn., National Academy Press, Washington, DC., USA., ISBN-13: 9780309048927, Pages: 176.
17.
Niewold, T.A., 2007. The nonantibiotic anti-inflammatory effect of antimicrobial growth promoters, the real mode of action? A hypothesis. Poult. Sci., 86: 605-609.
18.
Rick, W. and W.P. Fritsch, 1974. Chymotrypsin, Trypsin and Pepsin. In: Methods of Enzymatic Analysis, Bergmeyer, H.U. (Ed.). Vol. 2, Academic Press, New York, pp: 1006-1057.
19.
SAS, 1999. SAS/STAT User's Guide. Release 6.12, SAS Institute Inc., Cary, NC., USA.
20.
Saleha, A.A., Tin Tin Myaing, K.K. Ganapathy, I. Zulkifli, R. Raha and K. Arifah, 2009. Possible effect of antibiotic-supplemented feed and environment on the occurrence of multiple antibiotic resistant Escherichia coli in chickens. Int. J. Poultry Sci., 8: 28-31.