Research Article Open Access

Presence of Interferon-Gamma and IL-2 in Supernatants of Salmonella enteritidis-Immune Lymphokines

Authors

CORRESPONDING AUTHOR
Gabriela V. G-Verduzco
Departamento de Produccion Animal, Aves, FMVZ, UNAM,CD. Universitaria, Mexico City, Mexico D.F. 04510
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Guillermo Tellez
Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA
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Michael H. Kogut
Southern Plains Agricultural Research Center, USDA-ARS, 2881,F and B Road, College Station, TX 77845, USA
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Armando Isibasi
Unidad de Investigacion Medica en Inmunoquimica del Hospital de Especialidades del Centro Medico Nacional del IMSS, Mexico City, Mexico, D.F. 03020
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Vianney Ortiz-Navarrete
Departamento de Biomedicina Molecular del Centro de Investigacion y de Estudios Avanzados del IPN (CINVESTAV), Mexico City, Mexico, D.F. 07360
Published on: August 15, 2009
DOI 10.3923/ijps.2009.820.823
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Abstract

Investigations in our laboratories have indicated that an increased resistance to Salmonella enteritidis SE organ infectivity in chickens was conferred by the immunoprophylactic administration of SE-immune lymphokines (SE-ILK). Resistance has been associated with an enhanced heterophilic accumulation within 4 h of ILK injection. Further studies demonstrated that CxCLi2 is produced locally by the host in response to both the SE infection and the SE-ILK suggesting that IL-8 is a major chemotactic factor produced by the host, which aids in mediating the SE-ILK induced recruitment of heterophils to the site of SE invasion. In the present study, two bio-assays confirmed the presence of IFN and IL-2 functions in SE-ILK that may also participate in the establishment of the reported protection against Salmonella infections. The IL-2 and IFN effects detected in this work suggest that bird’s immune response develops similarly to that of mammals, with some features corresponding to the species.

Keywords:

Chickens, cytokines, inflammation, Salmonella

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How to Cite

G-Verduzco, G. V., Tellez, G., Kogut, M. H., Isibasi, A., & Ortiz-Navarrete, V. (2009). Presence of Interferon-Gamma and IL-2 in Supernatants of Salmonella enteritidis-Immune Lymphokines. International Journal of Poultry Science, 8(9), 820–823. https://doi.org/10.3923/ijps.2009.820.823
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