Effect of Induced Mutation on Pathogenicity Index of Avian Influenza Virus Subtype H7N3


Authors

  • Sofia Khanum Department of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan
  • Khalid Naeem National Reference Lab. for Poultry Diseases, Animal Sciences Institute, National Agricultural Research Centre, Park Road, Islamabad, Pakistan
  • Zaheer Ahmed National Reference Lab. for Poultry Diseases, Animal Sciences Institute, National Agricultural Research Centre, Park Road, Islamabad, Pakistan
  • Sadia Sattar National Reference Lab. for Poultry Diseases, Animal Sciences Institute, National Agricultural Research Centre, Park Road, Islamabad, Pakistan
  • Abdul Hameed Department of Biological Sciences, Quaid I Azam University, Islamabad, Pakistan

DOI:

https://doi.org/10.3923/ijps.2008.1132.1137

Keywords:

Avian Influenza, induced mutation, serotype H7N3

Abstract

Intravenous pathogenicity index (IVPI) of three Avian influenza virus (AIV) isolates of serotypes H7N3 was determined at their zero, 10 ,20 and 30th in ovo-passage levels to check the effect of mutation during passage on pathogenicity of the virus. For this purpose three local field isolates of AIV H7N3 were passaged in 9 day old chicken embryonated eggs. Each passaged isolate was subjected to biological evaluation at every 10th passage level. It was found that in-ovo passaging of viruses had both positive and negative effect on pathogenicity index of H7N3 isolates. It was also determined that among three isolates only one isolate showed increase in pathogenicity by passaging while the other two showed decline in their pathogenicity index. On the other hand repeat passaging helped to increase HA titers in all the isolates.

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Published

2008-10-15

Issue

Vol. 7 No. 11 (2008)

Section

Research Article

License

Copyright (c) 2008 Asian Network for Scientific Information

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

How to Cite

Khanum, S., Naeem, K., Ahmed, Z., Sattar, S., & Hameed, A. (2008). Effect of Induced Mutation on Pathogenicity Index of Avian Influenza Virus Subtype H7N3. International Journal of Poultry Science, 7(11), 1132–1137. https://doi.org/10.3923/ijps.2008.1132.1137