Effects of Vitamin D and Calcium for the Prevention of Osteoporosis at Various Stages of Life of Laying Hens-Review
DOI:
https://doi.org/10.3923/ijps.2018.405.409Keywords:
Calcium, egg production, laying hen, osteoporosis, vitamin DAbstract
Laying hens have been selected for high egg production in a prolonged period. This has negatively affected the health of laying hens, specifically in weakening their bones to the point of developing osteoporosis. Nutrients such as vitamin D and calcium have been studied in order to find a prevention for osteoporosis. The objective of this review was to examine the effects of these nutrients on bone turnover in laying hens in order to find a prevention for osteoporosis through nutritional strategies. Several studies have demonstrated that particulate forms of calcium enhance the absorption of calcium, and thus incorporation of calcium into the bone. Vitamin D has been shown to play a decisive role in blood calcium concentration, and osteoclast activity to break down bone; however, vitamin D continues to play a critical role in laying hen reproduction and is thus necessary. Further research should be done on the ideal concentration of particulate calcium sources and vitamin D in laying hens in order to maintain healthy bone strength and metabolism during the egg laying period.
References
National Institute of Aging, 2015. Osteoporosis: La usurpadora de los huesos. Department of Health and Human Services, NIH., National Institute of Aging, Gaithersburg, MD.
Randall, C.J. and S.R. Duff, 1988. Avulsion of the patellar ligament in osteopenic laying fowl. Vet. Rec., 123: 439-441.
Gregory, N.G., L.J. Wilkins, T.G. Knowles, P. Sorensen and T. van Nierkerk, 1994. Incidence of bone fractures in European layers. Proceedings of the 9th European Poultry Conference Vol. II. UK Branch of WPSA., Glasgow, UK., August, 1994, World's Poultry Science Association, pp: 126-128.
Brown, R.H., 1993. Egg producers concerned about loss of spent fowl slaughter market. Feedstuffs, 65: 1-1.
Bishop, S.C., R.H. Fleming, H.A. McCormack, D.K. Flock and C.C. Whitehead, 2000. Inheritance of bone characteristics affecting osteoporosis in laying hens. Br. Poult. Sci., 41: 33-40.
Prabhu, A.V., W. Luu, D. Li, L.J. Sharpe and A.J. Brown, 2016. DHCR7: A vital enzyme switch between cholesterol and vitamin D production. Progress Lipid Res., 64: 138-151.
Heaney, R.P. and L.A.G. Armas, 2014. Quantifying the vitamin D economy. Nutr. Rev., 73: 51-67.
Christakos, S., P. Dhawan, D. Ajibade, B.S. Benn, J. Feng and S.S. Joshi, 2010. Mechanisms involved in vitamin D mediated intestinal calcium absorption and in non-classical actions of vitamin D. J. Steroid Biochem. Mol. Biol., 121: 183-187.
Fleet, J.C. and R.D. Schoch, 2010. Molecular mechanisms for regulation of intestinal calcium absorption by vitamin D and other factors. Crit. Rev. Clin. Lab. Sci., 47: 181-195.
Kerschnitzki, M., A. Akiva, A.B. Shoham, N. Koifman and E. Shimoni et al., 2016. Transport of membrane-bound mineral particles in blood vessels during chicken embryonic bone development. Bone, 83: 65-72.
Kim, W.K., S.A. Bloomfield, T. Sugiyama and S.C. Ricke, 2012. Concepts and methods for understanding bone metabolism in laying hens. World's Poult. Sci. J., 68: 71-82.
Whitehead, C.C., 2004. Overview of bone biology in the egg-laying hen. Poult. Sci., 83: 193-199.
Fleming, R.H., H.A. McCormack and C.C. Whitehead, 1998. Bone structure and strength at different ages in laying hens and effects of dietary particulate limestone, vitamin K and ascorbic acid. Br. Poult. Sci., 39: 434-440.
Rangel, P.L., A. Rodriguez, K. Gutierrez, P.J. Sharp and C.G. Gutierrez, 2014. Subdominant hierarchical ovarian follicles are needed for steroidogenesis and ovulation in laying hens (Gallus domesticus). Anim. Reprod. Sci., 147: 144-153.
Dunn, I.C., A.B. Rodriguez‐Navarro, K. Mcdade, M. Schmutz and R. Preisinger et al., 2012. Genetic variation in eggshell crystal size and orientation is large and these traits are correlated with shell thickness and are associated with eggshell matrix protein markers. Anim. Genet., 43: 410-418.
Jiang, S., L. Cui, C. Shi, X. Ke, J. Luo and J. Hou, 2013. Effects of dietary energy and calcium levels on performance, egg shell quality and bone metabolism in hens. Vet. J., 198: 252-258.
Guinotte, F. and Y. Nys, 1991. Effects of particle size and origin of calcium sources on eggshell quality and bone mineralization in egg laying hens. Poult. Sci., 70: 583-592.
Tsonis, P.A., 1991. 1, 25-Dihydroxyvitamin D3 stimulates chondrogenesis of the chick limb bud mesenchymal cells. Dev. Biol., 143: 130-134.
Narbaitz, R. and C.P.W. Tsang, 1989. Vitamin D deficiency in the chick embryo: Effects on prehatching motility and on the growth and differentiation of bones, muscles and parathyroid glands. Calcif. Tissue Int., 44: 348-355.
Smith, E.L., H. Rashidi, J.M. Kanczler, K.M. Shakesheff and R.O. Oreffo, 2015. The effects of 1α, 25-dihydroxyvitamin D3 and transforming growth factor-β3 on bone development in an ex vivo organotypic culture system of embryonic chick femora. PloS One, Vol. 10, No. 4.
Wilson, S. and S.R.I. Duff, 1991. Effects of vitamin or mineral deficiency on the morphology of medullary bone in laying hens. Res. Vet. Sci., 50: 216-221.
Dacke, C.G., S. Arkle, D.J. Cook, I.M. Wormstone, S. Jones, M. Zaidi and Z.A. Bascal, 1993. Medullary bone and avian calcium regulation. J. Exp. Biol., 184: 63-88.
Dickson, I.R. and E. Kodicek, 1979. Effect of vitamin D deficiency on bone formation in the chick. Biochem. J., 182: 429-435.
Wasserman, R.H., 2004. Vitamin D and the dual processes of intestinal calcium absorption. J. Nutr., 134: 3137-3139.
Guinotte, F., J. Gautron, Y. Nys and A. Soumarmon, 1995. Calcium solubilization and retention in the gastrointestinal tract in chicks (Gallus domesticus) as a function of gastric acid secretion inhibition and of calcium carbonate particle size. Br. J. Nutr., 73: 125-139.
Mechanic, G.L., S.U. Toverud, W.K. Ramp and W.A. Gonnerman, 1975. The effect of vitamin D on the structural crosslinks and maturation of chick bone collagen. Biochim. Biophys. Acta (BBA)-Protein Struct., 393: 419-425.
Rodrigues, E.A., M.C.D. Oliveira, L.C. Cancherini, K.F. Duarte, L.F. Santana and O.M. Junqueira, 2013. Calcium in pre-laying and laying rations on the performance and quality of laying hen’s eggshell. Acta Scient. Anim. Sci., 35: 153-157.
Tyler, C., 1954. Studies on egg shells IV.-The site of deposition of radioactive calcium and phosphorus. J. Sci. Food Agric., 5: 335-339.
Cucco, M., M. Grenna and I. Pellegrino, 2017. Egg characteristics in relation to skipped days of laying in the grey partridge. Avian Biol. Res., 10: 231-240.
Comar, C.L. and J.C. Driggers, 1949. Secretion of radioactive calcium in the hen's egg. Science, 109: 282-282.
Wilson, S. and S.R. Duff, 1990. Morphology of medullary bone during the egg formation cycle. Res. Vet. Sci., 48: 216-220.
Candlish, J.K., 1971. The formation of mineral and organic matrix of fowl cortical and medullary bone during shell calcification. Br. Poult. Sci., 12: 119-127.
Fleming, R.H., H.A. McCormack, L. McTeir and C.C. Whitehead, 1998. Medullary bone and humeral breaking strength in laying hens. Res. Vet. Sci., 64: 63-67.
Safamehr, A., S. Hedatyati and M.H. Shahir, 2013. The effects of dietary calcium sources and vitamin D3 on egg quality and performance in laying hens. Iran. J. Applied Anim. Sci., 3: 167-175.
Persia, M.E., M. Higgins, T. Wang, D. Trample and E.A. Bobeck, 2013. Effects of long-term supplementation of laying hens with high concentrations of cholecalciferol on performance and egg quality. Poult. Sci., 92: 2930-2937.
Browning, L.C. and A.J. Cowieson, 2015. Interactive effects of vitamin D3 and strontium on performance, nutrient retention and bone mineral composition in laying hens. J. Sci. Food Agric., 95: 1080-1087.
Ravinder, K., B.M. Rathgeber, K.L. Thompson and J. MacIsaac, 2013. Uterine fluid proteins and egg quality characteristics for 2 commercial and 2 heritage laying hen lines in response to manipulation of dietary calcium and vitamin D3. Poult. Sci., 92: 2419-2432.
Downloads
Published
Issue
Section
License
Copyright (c) 2018 The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License.
This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.