Experimental Mycotoxicosis in Layer Induced by Ochratoxin A and its Amelioration with Herbomineral Toxin Binder Toxiroak
DOI:
https://doi.org/10.3923/ijps.2009.798.803Keywords:
Herbo-mineral, layer, ochratoxicosis, performance, toxin-binderAbstract
A study was conducted in 80 white leghorn 26 week old laying hen to evaluate toxic effects of ochratoxin A and preventive efficacy of herbomineral toxin binder product (Toxiroak®). Birds were randomly divided into four groups of 20 each. Group I served as control and given no treatment, Group II comprised healthy birds fed standard basal diet and administered Toxiroak@1.25 kg/tonne of feed for 60 days, birds of group III received ochratoxin A@1 ppm while those of group IV were given ochratoxin A@1 ppm and herbomineral toxin binder product Toxiroak@1.25 kg/tonne of feed for 60 days. Ochratoxin A adversely affects body weight gain, feed consumption, laying performance of hens besides haematobiochemical disturbances & severe immunosupression. However, supplementation of herbomineral toxin binder feed supplement has provided a moderate amelioration in mycotoxicosis.
References
Abdel-Wahhab, M.A., S.A. Nada and F.A. Khalil, 2002. Physiological and toxicological responses in rats fed aflatoxin-contaminated diet with or without sorbent materials. Anim. Feed Sci. Technol., 97: 209-219.
Aved, I.A., R. Dafella, A.F. Yogi and S.E. Adam, 1991. Effect of ochratoxin A on Lohaman type Chicks. Vet. Hum. Toxicol., 33: 357-360.
Borisava, L., M. Duparinova, M. Aleksondrov, T. Tacheva and A. Dzhurov et al., 1987. Experimental reduction of aflatoxicosis in broilers. Vet. Nauki, 24: 69-75.
Campbell, Jr. M.L., J.D. May, W.E. Huff and J.A. Doerr, 1983. Evaluation of immunity of young broiler chickens during simultaneous aflatoxicosis and ochratoxicosis. Poult. Sci., 62: 2138-2144.
Chang, C.F., W.E. Huff and P.B. Hamilton, 1979. A leucocytopenia induced in chickens by dietary ochratoxin A. Poult. Sci., 58: 555-558.
Doerr, J.A. and R.B. Huff, 1980. Interactive effects of aflatoxin and ochratoxin A on some blood constituents in broiler chickens. Poult. Sci., 59: 1600-1602.
Dwivedi, P. and R.B. Burns, 1984. Pathology of ochratoxicosis A in young broiler chicks. Res. Vet. Sci., 36: 92-103.
Elaroussi, M.A., F.R. Mohamed, E.M. El Barkouky, A.M. Atta, A.M. Abdou and M.H. Hatab, 2006. Experimental ochratoxicosis in broiler chickens. Avian Pathol., 35: 263-269.
Ghosh, R.C., H.V. Chauhan and S. Roy, 1990. Immunosupression in broilers under experiemental aflatoxicosis. Br. Vet. J., 146: 457-462.
Gibson, R.M., C.A. Bailey, L.F. Kubena, W.E. Huff and R.B. Harvey, 1990. Impact of L-phenylalanine supplementation on the performance of three-week-old broilers fed diets containing ochratoxin A. 1. Effects on body weight, feed conversion, relative organ weight and mortality. Poult. Sci., 69: 414-419.
Godbole, S.M., 1998. Immunomodulation by growell during experimental aflatoxicosis in chicks. M.Sc. Thesis, Dr. Panjabrao Deshmukh Krishi Vidyapeeth, Akola.
Huff, W.E., L.F. Kubena, R.B. Harvey and T.D. Phillips, 1992. Efficacy of hydrated sodium calcium aluminosilicate to reduce the individual and combined toxicity of aflatoxin and ochratoxin A. Poult. Sci., 71: 64-69.
Huff, W.E., L.F. Kubena and R.B. Harvey, 1988. Progression of ochratoxicosis in broiler chickens. Poult. Sci., 67: 1139-1146.
Jindal, N., S.K. Mahipal and N.K. Mahajan, 1993. Occurance of aflatoxin B1 toxicity in broilers by dietary supplementation of lysine, methionine and choline chloride. Int. J. Anim. Sci., 63: 71-73.
Johri, T.S. and C.K. Beura, 2000. Efficacy of avsorb+ feed supplement in alleviating adverse effects of Aflatoxins in broilers. CART Contract Res. Rep. Poult. Sci., 4: 2-4.
Kalorey, D.R., 1993. Effect of aflatoxin on humoral immune system of chicks. Ph.D. Thesis, Krishi Vidyapeeth, Akola, India.
Kalorey, D.R., N.A. Shete, V.C. Ingle, N.V. Kurkure and S.D. Harne, 2000. In vitro evaluation of antifungal and antitoxic activity of herbomineral premix. Proceedings of XXI Worlds Poultry Congress, Montreal, Canada.
Kubena, L.F., R.B. Harvey, T.D. Phillip and B.A. Clement, 1993. Effect of hydrated sodium calcium aluminosilicate on aflatoxicosis in broiler chicks. Poult. Sci., 72: 651-657.
Kumar, A., N. Jindal, C.L. Shukla, R.K. Asrani, D.R. Ledoux and G.E. Rottinghaus, 2004. Pathological changes in broiler chickens fed ochratoxin A and inoculated with Escherichia coli. Avian Pathol., 33: 413-417.
Kurkure, N.V., S.P. Pawar, S.M. Kognole, A.G. Bhandarkar, A.G. Ganorkar and D.R. Kalorey, 2000. Ameliorative effect of turmeric (Curcuma longa) in induced aflatoxicosis in cockerels. Indian J. Vet. Pathol., 24: 26-28.
Manning, R.O. and R.D. Wyatt, 1984. Toxicity of Aspergillus ochraceus contaminated wheat and different chemical forms of ochratoxin A in broiler chicks. Poult. Sci., 63: 458-465.
Mohiuddin, S.M., S.M.A. Warasi and M.V. Reddy, 1993. Haematological and biochemical changes in experimental ochratoxicosis in broiler chicken. Indian Vet. J., 70: 613-617.
NRC., 1998. Nutrient Requirements of Swine. 10th Edn., National Research Council, Washington, DC., USA.
O'Brien, E. and D.R. Dietrich, 2005. Ochratoxin A: The continuing enigma. Crit. Rev. Toxicol., 35: 33-60.
Page, R.K., G. Stewart, R. Wyatt, P. Bush, O.J. Fletcher, and J. Brown, 1980. Influence of low levels of ochratoxin A on egg production, egg-shell stains, and serum uric acid levels in Leghorn-type hens. Avian Dis., 24: 777-780.
Politis, I., K. Fegeros, S. Nitsch, G. Schatzmayr and D. Kantas, 2005. Use of Trichosporon mycotoxinivorans to suppress the effects of ochratoxicosis on the immune system of broiler chicks. Br. Poult. Sci., 46: 58-65.
Prior, M.G., C.S. Sisodia and J.B. Neil, 1981. Effects of ochratoxin A on egg production, body weight and feed intake in white leghorn hens. Poult. Sci., 6: 1145-1148.
Raina, J.S., K.S. Roy and B. Singh, 1991. Biochemical and histochemical studies in experiemental mycotoxicosis in chicks. Indian J. Anim. Sci., 62: 1276-1281.
Raju, M.L.V.N. and G. Devegowda, 2000. Influence of esterified glucamannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to indvidual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). Br. Poult. Sci., 41: 640-650.
Ramadevi, N.R., R. Gopalnaidu and P. Ravikumar, 2000. An assessment of the protective effect of bentonite on ochratoxicosis in broiler with reference to certain haematological profile. Indian Vet. J., 77: 303-306.
Randall, G.M. and F.H. Bird, 1979. The effect of exercise on the toxicity of aflatoxin B1 in chickens. Poult. Sci., 58: 1284-1288.
Sakhare, P.S., S.D. Harne, D.R. Kalorey, S.R. Warke, A.G. Bhandarker and N.V. Kurkure, 2007. Effect of toxiroak® polyherbal feed supplement during induced aflatoxicosis, ochratoxicosis and combined mycotoxicosis in broilers. Vet. Arch., 77: 129-146.
Santin, E., A.C. Paulillo, P.C. Maiorka, A.C. Alessi, E.L. Krabbe and A. Maiorka, 2002. The effects of ochratoxin/aluminosilicate interaction on the tissues and humoral immune response of broilers. Avian Pathol., 31: 73-79.
Scott, P.M., 1978. Mycotoxins in feed and ingredient and their origin. J. Food Prot., 41: 385-389.
Singh, G.S.P., H.V.S. Chauhan, G.H. Jha and K.K. Singh, 1990. Immunosuppression due to chronic ochratoxicosis in broiler chicks. J. Comp. Pathol., 103: 399-410.
Stoev, S.D., D. Djuvinov, T. Mirtcheva, D. Pavlov and P. Mantle, 2002. Studies on some feed additives giving partial protection against ochratoxin A toxicity in chicks. Toxicol. Lett., 135: 33-50.
Stoev, S.D., G. Anguelov, I. Ivanov and D. Pavlov, 2000. Influence of ochratoxin A and an extract of artichoke on the vaccinal immunity and health in broiler chicks. Exp. Toxicol. Pathol., 52: 43-55.
Stoev, S.D., M. Stefanov, S. Denev, B. Radic, A.M. Domijan and M. Peraica, 2004. Experimental mycotoxicosis in chickens induced by ochratoxin A and penicillic acid and intervention with natural plant extracts. Vet. Res. Commun., 28: 727-746.
Stoev, S.D., G. Aguelov, I. Ivanov and D. Pavlov, 2000. Influence of ochratoxin A and an extract of artichoke on the vaccinal immunity and health in broiler chicks. Exp. Toxicol. Pathol., 52: 43-55.
Tapia, M.O., 1985. A quantitative TLC method for analysis of aflatoxins, OA, zearalenone, T2 toxin and other mycotoxins in food stuff. Rev. Argentine Microbiol., 17: 183-186.
Thaxton, J.P., H.T. Tung and P.B. Hamilton, 1974. Immunosupression in chickens by aflatoxin. Poult. Sci., 53: 721-725.
Thompson, C.D., S. Whittingham, L.R. Mackay, S.K. Khoo, B.H. Toh and R.J. Stagg, 1975. Quantitation of cell mediated immunity: Response to dinitrochlorobenzene and ubiquitous antigen. Can. Med. J. Assoc. J., 112: 1078-1081.
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