Acute Effect of Oral Administration of Fructose on Blood Parameters and Hepatic Glycogen in Layer Chicks
DOI:
https://doi.org/10.3923/ijps.2017.56.59Keywords:
Carbohydrate, chick, free fatty acid, fructose, glycogenAbstract
Objective: The aim of the present study was to investigate the effect of oral administration of fructose on blood parameters and hepatic glycogen in chickens. Materials and Methods: Each chick was injected orally once only with fructose solution (80 mg/0.2 mL) after 12 h fasting. The levels of plasma glucose and Free Fatty Acid (FFA) and hepatic glycogen were measured at 1, 2 or 3 h after administration and compared with levels in 12 h fasted and ad libitum chicks. Results: Although no significant differences were detected in blood parameters between the ad libitum and fasting condition, the level of hepatic glycogen in the fasted chicks was lower than that in the ad libitum chicks (p<0.05). The plasma glucose level at 2 h was significantly lower than that at 1 h post-injection (p<0.05). The concentration of FFA at 1 h post-injection was significantly lower than that in the fasted chicks (p<0.05). Conclusion: These results suggest that the administration of fructose affects carbohydrate and lipid metabolism in chicks.
References
Hallfrisch, J., 1990. Metabolic effects of dietary fructose. FASEB J., 4: 2652-2660.
Matschinsky, F.M., 1990. Glucokinase as glucose sensor and metabolic signal generator in pancreatic β-cells and hepatocytes. Diabetes, 39: 647-652.
Vila, L., N. Roglans, V. Perna, R.M. Sanchez, M. Vazquez-Carrera, M. Alegret and J.C. Laguna, 2011. Liver AMP/ATP ratio and fructokinase expression are related to gender differences in AMPK activity and glucose intolerance in rats ingesting liquid fructose. J. Nutr. Biochem., 22: 741-751.
Martinez, F.J., R.A. Rizza and J.C. Romero, 1994. High-fructose feeding elicits insulin resistance, hyperinsulinism and hypertension in normal mongrel dogs. Hypertension, 23: 456-463.
Park, J., S. Lemieux, G.F. Lewis, A. Kuksis and G. Steiner, 1997. Chronic exogenous insulin and chronic carbohydrate supplementation increase de novo VLDL triglyceride fatty acid production in rats. J. Lipid Res., 38: 2529-2536.
Bantle, J.P., S.K. Raatz, W. Thomas and A. Georgopoulos, 2000. Effects of dietary fructose on plasma lipids in healthy subjects. Am. J. Clin. Nutr., 72: 1128-1134.
Elliott, S.S., N.L. Keim, J.S. Stern, K. Teff and P.J. Havel, 2002. Fructose, weight gain and the insulin resistance syndrome. Am. J. Clin. Nutr., 76: 911-922.
Stanhope, K.L., J.M. Schwarz, N.L. Keim, S.C. Griffen and A.A. Bremer et al., 2009. Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J. Clin. Invest., 119: 1322-1334.
Devendra, C., 1993. Sustainable animal production from small farm systems in South-East Asia. FAO Animal Production and Health Paper 106, FAO, Rome, Italy, pp: 1-6.
Devendra, C. and D. Thomas, 2002. Crop-animal interactions in mixed farming systems in Asia. Agric. Syst., 71: 27-40.
Goni, I., A. Brenes, C. Centeno, A. Viveros and F. Saura-Calixto et al., 2007. Effect of dietary grape pomace and vitamin E on growth performance, nutrient digestibility and susceptibility to meat lipid oxidation in chickens. Poult. Sci., 86: 508-516.
Ebrahimi, A., A.A.A. Qotbi, A. Seidavi, V. Laudadio and V. Tufarelli, 2013. Effect of different levels of dried sweet orange (Citrus sinensis) peel on broiler chickens growth performance. Archiv Tierzucht, 56: 11-17.
Akhlaghi, A., Y.J. Ahangari, M. Zhandi and E.D. Peebles, 2014. Reproductive performance, semen quality and fatty acid profile of spermatozoa in senescent broiler breeder roosters as enhanced by the long-term feeding of dried apple pomace. Anim. Reprod. Sci., 147: 64-73.
Erwan, E., V.S. Chowdhury, M. Nagasawa, R. Goda, T. Otsuka, S. Yasuo and M. Furuse, 2014. Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks. Life Sci., 109: 65-71.
Good, C., H. Kramer and M. Somogyi, 1933. The determination of glycogen. J. Biol. Chem., 100: 485-491.
Klasing, K.C., 1998. Carbohydrates. In: Comparative Avian Nutrition, Klasing, K.C. (Ed.). Chapter 8, CAB International, Oxon, UK., ISBN-13: 9780851992198, pp: 201-209.
Fitch, W.M., R. Hill and I.L. Chaikoff, 1959. The effect of fructose feeding on glycolytic enzyme activities of the normal rat liver. J. Biol. Chem., 234: 1048-1051.
Van den Berghe, G., 1978. Metabolic effects of fructose in the liver. Curr. Top. Cell. Regul., 13: 97-135.
Petersen, K.F., D. Laurent, C. Yu, G.W. Cline and G.I. Shulman, 2001. Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans. Diabetes, 50: 1263-1268.
Havel, P.J., 2005. Dietary fructose: Implications for dysregulation of energy homeostasis and lipid/carbohydrate metabolism. Nutr. Rev., 63: 133-157.
Hazelwood, R.L., 1986. Carbohydrate Metabolism. In: Avian Physiology, Sturkie, P.D. (Ed.). 4th Edn., Springer, New York, USA., pp: 303-325.
Stanhope, K.L. and P.J. Havel, 2009. Fructose consumption: Considerations for future research on its effects on adipose distribution, lipid metabolism and insulin sensitivity in humans. J. Nutr., 139: 1236S-1241S.
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