Diuretic Effects of Several Chemical and Herbal Compounds in Adult Laying Hens
DOI:
https://doi.org/10.3923/ijps.2010.247.253Keywords:
Diuretic effect, herbal and chemical compounds, laying hensAbstract
Diuretic agents have been used in the treatment of several situations such as cardiopulmonary and urinary diseases in humans and animals, but they have not been extensively studied in poultry. Some Iranian poultry producers traditionally use urotropin (hexamine), alhagi (Camelorum fisch) and malt beverage to get therapeutic effect in broiler or laying hens. Diuretics may be used after drug therapy in order to get rid of tissue residues and in some toxicity conditions in birds. The purpose of this study was to evaluate the diuretic properties of several herbal and chemical agents in adult laying hens. Adult laying hens were randomly divided into 9 groups, each group consisting of 5 birds. Specific doses of diuretics were administrated to anesthetized hens (with xylazine and ketamine) following 24 h off-feed period. Urine samples were collected for 2 h after drug administration. Blood samples were also taken at 90 min. The concentrations of chloride, albumin, glucose, creatinine, uric acid and urea nitrogen were measured in serum and urine samples. Urine volume and specific gravity, sodium and potassium concentrations were also determined in urine. Statistical analysis of data showed that furosemide had a positive significant effect on urine volume compared to other agents. Urotropin also increased the urine volume but this effect was not significant. With respect to the effects on electrolytes (sodium, potassium and chloride), intramuscular furosemide, oral urotropin and hydrochlorothiazide exerted some changes, but no consistent pattern was observed with respect to the other factors measured in serum and/or in urine. Diuretic effect was more pronounced following intramuscular administration of furosemide.
References
Berg, K.J., 1977. Acute acetylsalicylic acid poisoning: Treatment with forced alkaline diuresis and diuretics. Eur. J. Clin. Pharmacol., 12: 111-116.
Bartels, H., M. Bohmer and C. Heierli, 1972. Serum creatinine measurement. Clin. Chem. Acta, 34: 193-197.
Bosch, J.P., M.H. Goldstein, M.F. Levitt and T. Kahn, 1977. Effect of chronic furosemide administration on hydrogen and sodium excretion in the dog. Am. J. Physiol., 232: 397-404.
Brater, D.C., 1998. Diuretic therapy. N. Eng. J. Med., 339: 387-395.
Braun, E.J., 1982. Renal function. Comp. Biochem. Physiol., 71: 511-517.
Braun, E.J. and W.H. Dantzler, 1972. Function of mammalian-type and reptilian-type nephrons in kidney of desert quail. Am. J. Physiol., 22: 617-629.
Campbell, T.W. and E.H. Coles, 1986. Avian Veterinary Clinical Pathology. In: Veterinary Clinical Pathology, Coles, E.H. (Ed.). Saunders, Philadelphia, pp: 200-350.
Cohen, M.R., E. Hinsch, R. Vergona, J. Ryan, S.J. Kolis and W.A. Schwartz, 1976. A comparative diuretic and tissue distribution study of bumetanide and furosemide in the dog. J. Pharmacol. Exp. Ther., 197: 697-702.
Czaja, J., H. Moder, W. Wlather, J. Boretius and K. Wandt, 1983. Treatment of acute and chronic bovine mastitis with injectable Rhodovet, with reference to the clinical course. Mea. Fur. Vet., 38: 641-644.
Dein, F.J., 1986. Hematology. In: Clinical Avian Medicine and Surgery, Harrison, G.J. and L.R. Harrison (Eds.). Saunders, Philadelphia, pp: 174-191.
Dicker, S.E. and J. Haslam, 1966. Water diuresis in the domestic fowl. J. Physiol., 183: 225-235.
Dormans, T.P., P.G. Gerlag, F.G. Russel and P. Smiths, 1998. Combination diuretic therapy in severe congestive heart failure. Drugs, 55: 165-172.
Doumas, B.T., W.A. Watson and H.G. Biggs, 1971. Albumin standards and the measurement of serum albumin with bromcresol green. Clin. Chim. Acta, 31: 87-96.
Emery, N., T.L. Poulson and W.B. Kinter, 1972. Production of concentrated urine by avian kidneys. Am. J. Physiol., 223: 180-187.
Evans, R.T., 1968. Manual and automated methods for measuring urea based on a modification of its reaction with diacetyl monoxime and thiosemicarbazide. J. Clin. Pathol., 21: 527-529.
Fabiny, D.L. and G. Erthinghausen, 1971. Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clin. Chem., 17: 696-700.
Gronwell, R., 1985. Effect of diuresis on urinary excretion and creatinine clearance in the horse. Am. J. Vet. Res., 46: 1616-1618.
Hirai, J., H. Miyazaki and T. Taneike, 1992. The pharmacokinetics and pharmacodynamics of furosemide in the anesthetized dog. J. Vet. Pharmacol. Ther., 15: 231-239.
Kang, S.D. and J.M. Kim, 2005. Polyuria after surgery of ruptured cerebral aneurysm: With special reference to the administration of osmotic diuretics. J. Korean Neurosurgical Soc., 38: 431-434.
Klatt, P., R. Muschaweck, W. Bossaller, K.O. Magerkurth and O. Vanderbeke, 1975. Method of collecting urine and comparative investigation of quantities excreted by cats and dogs after administration of furosemide. Am. J. Vet. Res., 36: 919-923.
Laverty, G. and W.H. Dantzler, 1982. Micropuncture of superficial nephrons in avian (Sturnus vulgaris) kidney. Am. J. Physiol., 243: F561-F569.
Layton, H.E., J.M. Davies, G. Casott and E.J. Braun, 2000. Mathematical model of an avian urine concentrating mechanism. Am. J. Renal Physiol., 279: F1139-F1160.
McNabb, R.A., 1974. Urate and cation interactions in the liquid and percipitated fractions of avian urine and speculations on their physico-chemical state. Comp. Biochem. Physiol., 48: 45-54.
McNabb, F.M. and R.A. McNabb, 1975. Proportions of ammonia, urea, urate and total nitrogen in avian urine and quantitative methods for their analysis on a single urine sample. Poult. Sci., 54: 1498-1505.
Okumura, J., 1976. Method of colostomy and cannulation of the chicken. Br. Poult. Sci., 17: 547-551.
Puschett, J.B., 1981. Sites and mechanisms of action of diuretics in the kidney. J. Clin. Pharmacol., 21: 564-574.
Reece, R.L. and R.K. Hobbie, 1972. Computer evaluation of chemistry values: A reporting and diagnostic aid. Am. J. Clin. Pathol., 57: 664-675.
Rodes, J., 1996. Pathogenesis and treatment of ascites. J. Int. Med., 240: 111-114.
Roscelli, J.D., C.E. Yu and W.M. Southgate, 1970. Management of salt poisoning in an extremely low birth weight infant. Science, 169: 775-776.
Roudebush, P., T.A. Allen, N.F. Kuehn, J.H. Magerkurth and T.L. Bowers, 1994. The effect of combined therapy with captopril, furosemide and a sodium-restricted diet on serum electrolyte concentrations and renal function in normal dogs and dogs with congestive heart failure. J. Vet. Inter. Med., 8: 337-342.
Selye, H., 1969. Mercury poisoning: Prevention by spironolactone. Science, 164: 842-843.
Selye, H., M. Krajny and L. Savoie, 2006. Digoxin poisoning: Prevention by spironolactone. J. Pharm. Sci., 58: 1055-1059.
Stephens, G.A. and F.M. Robertson, 1985. Renal response to diuretics in the turtle. J. Comp. Physiol., 155: 387-393.
Tietz, N., 1976. Fundamentals of Clinical Chemistry. W. B. Saunders Publishing, Philadelphia.
Vestweber, J.G.E., F.K. Al-Ani and D.E. Johnson, 1989. Udder edema in cattle: Effects of diuretics (furosemide, hydrochlorothiazide, acetazolamide, and 50% dextrose) on serum and urine electrolytes. Am. J. Vet. Res., 50: 1323-1328.
Wideman, R.F., M. Ismail, Y.K. Kirby, W.G. Bottje, R.W. Moore and R.C. Vardeman, 1995. Furosemide reduces the incidence of pulmonary hypertension syndrome (ascites) in broilers exposed to cool environmental temperatures. Poult. Sci., 74: 314-322.
Zimmerman, M.B., E.M. Stricker and E.H. Blaine, 1978. Water and NaCl intake after furosemide treatment in sheep Ovis aires. Comp. Physiol. Psych., 92: 501-510.
Barham, D. and P. Trinder, 1972. An improved colour reagent for the determination of blood glucose by the oxidase system. Analyst, 97: 142-145.
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